At 5 years, any moderate or marked clinician-assessed normal tissue effects in the breast or chest wall was reported for 98 of 986 (9♹%) 40 Gy patients, 155 (15♴%) of 1005 27 Gy patients, and 121 of 1020 (11♹%) 26 Gy patients. 5-year incidence of ipsilateral breast tumour relapse after 40 Gy was 2♱% (1♴ to 3♱) estimated absolute differences versus 40 Gy in 15 fractions were −0♳% (−1♰ to 0♹) for 27 Gy in five fractions (probability of incorrectly accepting an inferior five-fraction schedule: p=0♰022 vs 40 Gy in 15 fractions) and −0♷% (−1♳ to 0♳) for 26 Gy in five fractions (p=0♰0019 vs 40 Gy in 15 fractions). At a median follow-up of 71♵ months (IQR 71♳ to 71♷), the primary endpoint event occurred in 79 patients (31 in the 40 Gy group, 27 in the 27 Gy group, and 21 in the 26 Gy group) HRs versus 40 Gy in 15 fractions were 0♸6 (95% CI 0♵1 to 1♴4) for 27 Gy in five fractions and 0♶7 (0♳8 to 1♱6) for 26 Gy in five fractions. The Lancet Regional Health – Western Pacificīetween Nov 24, 2011, and June 19, 2014, we recruited and obtained consent from 4096 patients from 97 UK centres, of whom 1361 were assigned to the 40 Gy schedule, 1367 to the 27 Gy schedule, and 1368 to the 26 Gy schedule.The Lancet Regional Health – Southeast Asia.The Lancet Gastroenterology & Hepatology.
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